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- #Free data recovery comparable to cd roller trial#
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Treatment approaches vary, from a watch‐and‐wait strategy to monotherapy with anti‐CD20 antibody to immunochemotherapy. FL presents a variable clinical course but is ultimately incurable. Taken together, we believe these data support a paradigm shift in the treatment of FL – moving from combination immunochemotherapy to chemotherapy‐free immunotherapy.įollicular lymphoma (FL) is the most common form of indolent non‐Hodgkin lymphoma (NHL) in the United States and Europe and accounts for roughly 20% of NHL cases globally (Perry et al, 2016 Teras et al, 2016). Finally, using an in vitro model of myeloid differentiation, we demonstrated that lenalidomide caused a reversible arrest in neutrophil maturation that was distinct from a cytotoxic chemotherapeutic agent, which may help explain the lower rates of neutropenia observed with R 2 versus R‐chemotherapy.
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#Free data recovery comparable to cd roller trial#
Immunophenotyping of FL patient samples from a phase 3 trial revealed that R 2 treatment increased circulating T‐ and NK‐cell counts, while R‐chemotherapy was associated with reduced cell numbers.
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While single‐agent lenalidomide and rituximab increased formation of lytic NK cell immunological synapses with primary FL tumour cells, the combination was superior and correlated with enhanced cytotoxicity. In combination with rituximab, lenalidomide improved antibody‐dependent cellular cytotoxicity in sensitive and chemo‐resistant FL cells, via a cereblon‐dependent mechanism. Here, we show that lenalidomide reactivated dysfunctional T and Natural Killer ( NK) cells ex vivo from FL patients by enhancing proliferative capacity and T‐helper cell type 1 (Th1) cytokine release. In phase 2 studies, lenalidomide combined with rituximab (R 2) has shown clinical synergy in front‐line and relapsed/refractory FL.
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Chemotherapy plus rituximab has been the mainstay of treatment for follicular lymphoma ( FL) for two decades but is associated with immunosuppression and relapse.